Home People Cytosim Publications Misc


julio

Julio Belmonte

Postdoc

I am funded by an EIPOD fellowship between the Leptin and Nedelec groups. Development of multi-cellular organisms involves coordinated large-scale changes of tissues, where cells differentiate, change shape and produce local deforming forces that give rise to new structures. In my project I combine experimental and simulation techniques to understand how different cells in the Drosophila embryo generate and transmit forces during gastrulation.

francois

Francois Nedelec

Principal Investigator

Our long-term research objective is to understand cytoskeletal organization in living cells, with an emphasis on mitosis. We develop in-vitro assays, quantitative image analysis and cytosim, a computer simulation to study cellular architecture from a mechanistic perspective, modeling the interactions of fibers and associated proteins such as molecular motors.

kasia

Manuel Lera Ramirez

PhD Student

Mitotic spindles are bipolar strucutres made of microtubules, that form in eukaryotic cells during mitosis to segregate chromosomes to the two daughter cells. Its correct assembly, positioning and timely movements are crucial to safeguard a normal outcome of mitosis. The work of many cell biologists, biophysicist in the past 50 years have given us a precise idea of the components of the spindle, but we still lack a model that can explain mechanistically how these components assemble to form the spindle.