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Our publications:

confocal J. Belmonte, M. Leptin and F. Nedelec
A Theory That Predicts Behaviors Of Disordered Cytoskeletal Networks.
Molecular Systems Biology, in press (2017)
confocal C.P. Descovich, D.B. Cortes, S. Ryan, J. Nash, Li Zhang, P.S. Maddox, F. Nedelec, A. Shaub Maddox
Crosslinkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis.
preprint (2017)
confocal S. Dmitrieff and F. Nedelec
ConfocalGN : a minimalistic confocal image generator.
SoftwareX, in press (2017)
myotube P. Gimpel1, Y.L. Lee, R. M. Sobota, A. Calvi, V. Koullourou, R. Patel, K. Mamchaoui, F. Nedelec, S. Shackleton, J. Schmoranzer, B. Burke, B. Cadot1* and E. R. Gomes*
Nesprin-1α-dependent microtubule nucleation from the nuclear envelope via Akap450 is necessary for nuclear positioning in muscle cells.
in press (2017)
live-cortex W.Y. Ding, H.T. Ong, Y. Hara, J. Wongsantichon, Y. Toyama, R. Robinson, F. Nedelec and R. Zaidel-Bar
Plastin increases cortical connectivity facilitating robust polarization and timely cytokinesis
Journal of Cell Biology (2017)
platelet S. Dmitrieff, A. Alsina, A. Mathur and F. Nédélec.
Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species
PNAS vol. 114 n 17 (2017)
preconfig F. Nédélec
Preconfig: a versatile configuration file generator for varying parameters
Journal of Open Research Software, 5(1) p.9 (2017)
ashbya R. Gibeaux, A. Z. Politi, P. Philippsen and F. Nédélec.
Mechanism of Nuclear Movements in a Multinucleated Cell
MBoC in press (2017)
internalization J-L. Maitre, H. Turlier, R. Illukkumbura, B. Eismann, R. Niwayama, F. Nédélec and T. Hiiragi.
Asymmetric division of contractile domains couples cell positioning and fate specification
Nature, 536, 344-348, August 2016
centering G. Letort, F. Nedelec, L. Blanchoin and M. Thery.
Centrosome centering and decentering by microtubule network rearrangement
Molecular Biology of the Cell, July 2016
actin-force Dmitrieff S and Nedelec F
Amplification of actin polymerization forces
Journal of Cell Biology vol. 212 (7) March 2016
mechanisms Belmonte J and Nedelec F
Large-scale microtubule networks contract quite well
eLife insight article (2016)
C-elegans embryo De Simone A, Nedelec F and Gönczy P
Dynein transmits polarized actomyosin cortical flows to promote centrosome separation
Cell Reports Vol 14 (9) March 2016
Cell Reportsdoipdf
actin-pattern Ennomani H, Letort G, Guérin C, Martiel J-L, Cao W, Nedelec F, De La Cruz E M, Thery M and Blanchoin L
Architecture and connectivity govern actin network contractility
Current Biology Vol 26 (5) 2016
Curr. Biol.doipdf
endocytosis Dmitrieff S and Nedelec F
Membrane Mechanics of Endocytosis in Cells with Turgor
PLOS Computational Biology Oct. 2015;
mouse-embryo Maitre J-L, Niwayama R, Turlier H, Nedelec F and Hiiragi T
Pulsatile cell-autonomous contractility drives compaction in the mouse embryo
Nature Cell Biology 2015;
actin-pattern Letort G, Politi A, Ennomani H, Thery M, Nedelec F and Blanchoin L
Geometrical and mechanical properties control actin filament organization
PLOS Computational Biology 2015 11(5): e1004245
quantification Picco A, Mund M, Ries J, Nedelec F and Kaksonen M
Visualizing the Functional Architecture of the Endocytic Machinery
eLife 2015; 10.7554/eLife.04535
compressed spindle Ward J, Roque H, Antony C and Nedelec F
Mechanical Design Principles of a Mitotic Spindle
eLife 2014; 10.7554/eLife.03398
diffusion Mori M, Somogyi K, Kondo H, Monnier N, Falk H, Machado P, Bathe M, Nedelec F and Lenart P
An Arp2/3 nucleated F-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes
Current Biology 2014 Jun 16;24(12):1421-8
Curr Biol.doipdf
spindles Pugieux C, Dmitrieff S, Tarnawska C and Nedelec F
Spindle assembly on immobilized chromatin micropatterns
Methods in Enzymology; 540:435-448; 2014
aster Athale C, Dinarina A, Nedelec F and Karsenti E
Collective behavior of minus-ended motors in mitotic microtubule asters gliding towards DNA
Physical Biology; 11, 016008; 2014
Phys. Biol.doi
spindles Tarnawska C, Pugieux C and Nedelec F
Mitotic spindle assembly on chromatin patterns made with deep UV photochemistry
Methods in Cell Biology; 120, 3–17; 2014
bubbles Wennekamp S, Mesecke S, Nedelec F and Hiiragi T
A self-organization framework for symmetry breaking in the mammalian embryo
Nature Reviews Molecular Cell Biology; 2013
Nature Reviewsdoi
karyogamy Gibeaux R, Politi A, Nedelec F, Antony C and Knop M
Spindle pole body-anchored Kar3 drives the nucleus along microtubules from another nucleus in preparation for nuclear fusion during yeast karyogamy
Genes & Development; 2013
pattern Rupp B and Nedelec F
Patterns of molecular motors that guide and sort filaments
Lab on a Chip; 2012
Supplementary (html5)Supplementary
Package to run cytosim on Mac OSX
spindle Loughlin R, Wilbur J, McNally F, Nedelec F, Heald R
Katanin contributes to interspecies spindle length scaling in Xenopus
Cell 147:1397-1407; 2011
spindle Petry S, Pugieux C, Nedelec F, Vale R
Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts
PNAS; August 2011
spindle-sim Loughlin R, Heald R and Nedelec F
A computational model predicts Xenopus meiotic spindle organization
Journal of Cell Biology, vol. 191 no. 7 1239-1249; Dec 2010
Supplementarybiosights videolarge snapshot (500K)long simulation (QT movie)
Recorded simulation (Mac OSX, dmg 50MB)Live simulation (Mac OSX, dmg 1.5MB)
chromosomes Renshaw M, Ward J, Kanemaki M, Natsume K, Nedelec F, Tanaka T
Condensins promote chromosome recoiling during early anaphase to complete sister chromatid separation
Developmental Cell 19 (2); Aug 2010
Dev CelldoiPMC2938479pdf
diagram Ward J, Nedelec F
Computational cell biology at the home of the helix
[meeting report]
EMBO reports 11 413-415; Feb 2010.
EMBO reportsdoiPMC2892329pdf
m/s Pugieux C, Nedelec F
La chromatine faconne le fuseau mitotique
[This review in French summarizes the results of Chromatin shapes the mitotic spindle.]
Medecine/Sciences 26 (2) 139-142; Feb 2010.
model Brun L, Rupp B, Ward J, Nedelec F
A theory of microtubule catastrophes and their regulation
PNAS 106 (50) 21173-21178; Dec 2009.
PNASSupplementaryNews & ViewsdoiPMC2795527pdf
kymograph Fu C, Ward J, Loiodice I, Velve-Casquillas G, Nedelec F, Phong T
Phospho-regulated interaction between kinesin-6 klp9p and microtubule bundler Ase1p promotes spindle elongation
Developmental Cell 17 (2), 257-267, Aug 2009.
Dev CelldoiPMC2997714pdf
spindles Dinarina A, Pugieux C, Mora Corral M, Loose M, Spatz J, Karsenti E, Nedelec F
Chromatin shapes the mitotic spindle
Cell 138 (3), 502-513, Aug 2009.
CelldoiNews & ViewsTeaser (QT video)pdf
vesicle Pinot M, Chesnel F, Kubiak JZ, Arnal I, Nedelec F, Gueroui Z
Effects of confinement on the self-organization of microtubules and motors
Current Biology 19 (11), 954-960, May 2009.
Curr Bioldoipdf
pombe Foethke D, Makushok T, Brunner D, Nedelec F
Force and Length-dependent catastrophe activities explain interphase microtubule organization in fission yeast
Molecular Systems Biology 5:241, Mar 2009.
MSBdoiPMC2671915pdfSupp (pdf)FAQNews & ViewsMovies and simulation

gradient Athale C, Dinarina A, Mora Corral M, Pugieux C, Nedelec F, Karsenti E
Regulation of microtubule dynamics by reaction cascades around chromosomes
Science 322 no. 5905, 1243-1247, Nov 2008.
larva Jekely G, Colombelli J, Hausen H, Guy K, Stelzer E, Nedelec F, Arendt D
Mechanism of phototaxis in marine zooplankton
Nature 456, 395-399, Nov 2008.
NaturedoiNews & ViewsCommentarySimulationpdf
asters Channels W, Nedelec F, Zheng Y, Iglesias P
Spatial regulation improves antiparallel microtubule overlap during mitotic spindle assembly
Biophysical Journal 94 (7), 2598-2609, Dec 2007.
spiral Nedelec F, Foethke D
Collective Langevin dynamics of flexible cytoskeletal fibers
New Journal of Physics 9 (11) 427, Nov 2007.
NJPdoiMatlab development codepdf
Simulation (mac, disk-image, 1MB)Simulation (windows, zip file 4MB)
This article describes the mathematical foundations of cytosim
icon Kozlowski C, Srayko M, Nedelec F
Cortical microtubule contacts position the spindle in C. elegans embryos
Cell 129, 499-510, May 2007.
CelldoiNews & ViewsCommentarySupplementary datapdf
Simulation (Mac OSX disk-image, 34 MB)
cell Janson M, Loughlin R, Loiodice I, Fu C, Brunner D, Nedelec F, Tran P
Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast
Cell 128, 357-68, Jan 2007.
CelldoiCommentarySupplementary data & Moviespdf
Simulation for Mac OSX (zip file with disk-image, 9 MB)Simulation for Windows (zip file, 23 MB)
icon Karsenti E, Nedelec F, Surrey T
Modelling microtubules patterns (review)
Nature Cell Biology 8(11), 1204-11, 2006
icon Goshima G, Nedelec F, Vale R
Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins
Journal of Cell Biology 171, 229-240, 2005.
Simulation (Mac OSX disk-image, 1.4 MB)Simulation (Windows tar file, 9 MB)
icon Karsenti E and Nedelec F
The mitotic spindle and actin tails
Biology of the Cell 96(3): 237-40; 2004.
PS: Some people found our citation missleading: we cite more recent work, but thermal ratchets for actin polymerization were introduced by Peskin, Odell and Oster (Biophysical J. 1993, July; 65(1)316-324).
icon Nedelec F, Surrey T, Karsenti E
Self-organisation and forces in the microtubule cytoskeleton
Current Opinion in Cell Biology 15(1): 118-24; 2003.
simulation Nedelec F
Computer simulations reveal motor properties generating stable anti-parallel microtubule interactions
Journal of Cell Biology 158(6): 1005-1015; 2002.
JCBdoi Supplementary materialPMC2173220pdf
dynamics Nedelec F and Surrey T
Dynamics of microtubule aster formation by motor complexes
C. R. Acad. Sci. Paris, t.2 Serie iv: 841-847; 2001.
pattern Surrey T, Nedelec F, Leibler S and Karsenti E
Physical properties determining self-organization of motors and microtubules
Science 292: 1167-1171; 2001.
Sciencedoi Supplementary materialpdf
vortices Nedelec F, Surrey T, and Maggs A. C.
Dynamic concentration of motors in microtubule arrays
Phys. Rev. Lett. 86: 3192-3195; 2001.
vortices Nedelec F and Surrey T
De l'action collective des moteurs a l'ordre cellulaire
Medecine/Sciences 16: 739-744; 2000.
(review in french)
asters Nedelec F and Surrey T
Assaying spatial organization of microtubules by kinesin Motors
Kinesin Protocols, Methods in Molecular Biology 164: 213-222; 2000.
vortex Surrey T, Elowitz M, Wolf PE, Yang F, Nedelec F, Shokat K and Leibler S.
Chromophore-assisted light inactivation and self-Organization of microtubules and motors
Proc. Nat. Acad. Sci. USA, 95: 4293-4298; 1998.
vortex Nedelec F, Surrey T, Maggs A.C. and Leibler S.
Self-organization of microtubules and motors
Nature 389: 305-308; 1997.
NatureImages and moviespdf
vortex Nedelec F
Auto-organisation d'un melange de microtubules et de moteurs
Thesis Dissertation, Orsay University; 1998.
PS chapters
Except for the abstract, this is written in French.

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